Um protocolo simples e eficiente para a reação de knoevenagel de benzilidenomalononitrilas e avaliação da atividade larvicida em Aedes aegypti

Abstract

Mosquitoes of the genus Aedes are responsible for dengue, yellow fever, chikungunya and Zika. Although important advances have emerged in the development of alternative methods for mosquito control, chemical insecticides remain a vital part of integrated control programs. In this paper were synthetized benzylidenemalononitrile derivatives in good yields (71-99%) using only water and glycerol at room temperature. A study of the larvicidal activity between benzylidenemalononitriles showed that the compound 2e (R= 4-Cl) possesses excellent larvicidal activity (LC50 and LC90 of 9.42 and 15.02, respectively at 24 h). A study of molecular docking was applied to identify the type of interaction of compound 2e with binding sites at the enzyme acetylcholinesterase. The profile of the interaction showed a score 48.9795 with five bonds at three different amino acids