Terapia fotodinâmica no reparo de deiscência de ferida operatória pós-cesárea: estudo piloto de um ensaio clínico randomizado

Abstract

Tissue photoactivation techniques can work as therapeutic alternatives to optimize the approach to skin wounds in a hospital environment and are of great value for reducing repair time. Photodynamic Therapy makes cells and microorganisms unfeasible by combining a photoactive substance, light and local oxygen. It can work as a therapeutic alternative to optimize the approach to skin wounds, favoring the reduction of repair time. This investigation aims to evaluate the effectiveness of photodynamic therapy in surgical dehiscence of patients admitted to a public maternity hospital in the Brazilian Amazon. This is a randomized controlled clinical trial, double blind, with a quantitative approach, whose results reports were described based on the statement CONSORT 2010. Twelve participants who presented post-cesarean surgical dehiscences were randomly distributed among group 1 - PDT using on the wounds methylene blue 1% activated by laser 660 nm 90J / cm2 and group 2 - AM, using methylene blue without irradiation. The outcome evaluated was the percentage of reduction in the area of surgical dehiscence. As for the results, G1 - amTFD showed a significant difference between the initial and final areas of the lesions (Wilcoxon p-value = 0.028), which did not occur in G2 - amC (Wilcoxon p-value = 0.225). The comparison of the dehiscence reduction percentages between the two treatments shows a significant difference (p-value = 0.001 Student's t test) between the groups. The study's limitation was the convenience sample, which points to the design of a randomized clinical trial to assess the effectiveness of Photodynamic Therapy for the treatment of surgical dehiscences. It is concluded that the dehiscences treated with PDT showed better clinical evolution compared to the control. Thus, PDT mediated by methylene blue and red laser was effective in tissue repair in surgical dehiscences, in the experimental conditions of this study. Keywords: