Obtenção de uma nano-emulsão à base de ajurú (Chrysobalanus icaco L.) utilizando o óleo das sementes e a fase aquosa flavonoídica obtida dos frutos

Abstract

The fruits from ajuru (Chrysobalanus icaco), a plant species belonging to the Chrysobalanaceae family, are an interesting source of bioactive flavonoids. In spite of its functional properties, the utilization of fruits derivatives for innovative formulations is scarce. In this context, the present study presents a novel approach for utilization of two ajuru-whole fruit herbal extracts in order to achieve an optimal phytonano-emulsion. The colloidal system prepared with the oil from seeds (required hydrophilic-lipophilic balance value = 14, determined with a blend of polysorbate 80/sorbitan monooleate) and a flavonoid aqueous phase (0.19 ± 0.04 mg/mL of flavonoids) presented mean size diameter and polydispersity index around 150 nm and 0.250, respectively. These results were lower than the nano-emulsion prepared with deionized water, being the last also presenting a broader size distribution during the storage. The results highlights the importance of intrinsic bioactive compounds as endogenous phytocolloids stabilizers, contributing to the state of art of phytopharmaceutical nanobiotechnology and opening perspectives for utilization of fractions of extracts containing flavonoids with oils of the same therapeutic plant, therefore obtaining suitable prototypes that can be further accessed for their bioactive potential.